<p>“High Treg” Inflammations Promote (Most) Non-Hematologic Cancers While “Low Treg” Inflammations Promote Lymphoid Cancers</p>
نویسندگان
چکیده
منابع مشابه
Donor double-negative Treg promote allogeneic mixed chimerism and tolerance.
Bone marrow (BM) transplantation is an efficient approach to develop donor-specific tolerance and prevent chronic rejection. Allogeneic BM transplantation is limited by donor T cell-mediated graft-versus-host disease, requirement of cytoreduction and high numbers of BM cells. In addition of these drawbacks, recent studies demonstrate that not only T cells, but also NK cells can mediate BM rejec...
متن کاملDynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Tregs control various functions of effector T cells; however, where and how Tregs exert their immunomodulatory effects remain poorly understood. Here we developed a murine model of adoptive T cell therapy and found that Tregs induce a dysfunctional state in tumor-infiltrating CTLs that resembles T cell exhaustion and is characterized by low expression of effector cytokines, inefficient cytotoxi...
متن کاملChronic Inflammations of Lymphatic Glands in Rangoon
The above is not difficult to understand when it is remembered how frequent and progressive tubercle of the lungs is in Rangoon, and how futile any treatment (including the open air treatment) is in its arrest. Excluding the evidently tubercular cases, a majority of other enlarged chronically inflamed lymphatic glands remains. They appear to be of syphilitic origin. While plenty of stress is la...
متن کاملType 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Immune tolerance is executed partly by Foxp3(+)regulatory T (Treg) cells, which suppress autoreactive T cells. In autoimmune type 1 diabetes (T1D) impaired tolerance promotes destruction of insulin-producing β-cells. The development of autoantigen-specific vaccination strategies for Foxp3(+)Treg-induction and prevention of islet autoimmunity in patients is still in its infancy. Here, using huma...
متن کاملSmall Doses of Antimony in Inflammations
fact that Dr. Kent Spender, of Bath, had pointed out in the March 1885 number of the Practitioner, that antimony in frequently repeated smnll doses ?th of a grain of tartar emetic, every hour or two hours, has the power of completely dissipating early local inflammations. Acting on Dr. Spender's suggestion, the treatment of surgical inflammation by antimony in small doses, frequently repeated, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Inflammation Research
سال: 2020
ISSN: 1178-7031
DOI: 10.2147/jir.s249384